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Lipid droplets accumulate in surviving HIV infected macrophages and associate with enlarged mitochondria Lipid dysregulation is a well-documented problem in the HIV infected population, and it is mostly associated with foam macrophages (uninfected and HIV infected) that survive for extended periods of time, resulting in increased risk for cardiovascular disease, atherosclerosis, and dementia 45,46,47,48

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Fatty acids are classified into saturated fatty acids, monounsaturated fatty acids, and polyunsaturated fatty acids (PUFAs) based on the degree of saturation of the fatty acid hydrocarbon chain