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In paclitaxel-treated animals, the upregulation of ATF3, a marker of nerve injury, was observed in DRG neurons (Peters et al., 2007

In April 2023, the thrombin inhibitor Argatroban concluded a Phase IV clinical trial in IS (NCT03740958) and was found to significantly reduce adverse prognosis when used in combination with Aspirin (Peng, 2023)