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Carcinogenesis 18 (4): 641644

2.13.3 Native mass spectrometry (nMS) Native mass spectrometry (nMS, which is a form of electrospray ionization mass spectrometry (ESI-MS)), being a relatively recent addition to the analytical toolbox of mass spectrometry, can be used to measure the size, stoichiometry, and interactions of macromolecules (such as proteins) in their native, folded state, thereby directly exploring the different conformational components in terms of geometry and structural compactness (Konijnenberg et al., 2015

Silencing PLK1 expression via siRNAs can inhibit the cell cycle progression and initiates the apoptosis of cancer cells, holding significant promise for cancer therapy 51,52