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Clinically, many late-onset MADD patients respond dramatically to high-dose riboflavin (100400 mg/day), confirming residual enzyme function amenable to cofactor restorationclassifying MADD as a prototype FAD-responsive metabolic myopathy (70)

10.1055/s-0032-1327734 116 ShabkhizanR.AvciC

Palmitoylethanolamide (PEA) is an 18-carbon long- chain fatty acid

For example, muscle overuse-induced cysteine oxidation and its intermediate cysteine sulfinic acid oxidation result in a reduced level of taurine and glutathione synthesis (GSH), ultimately compromising the taurine-induced benefits in the muscle, such as influencing GSH level and glutathionylation (Qin et al., 2013)