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Damaged intestinal barrier can facilitate the development of local diseases such as irritable bowel disease, inflammatory bowel disease or celiac disease, but also the development of systemic inflammatory diseases such as rheumatoid arthritis, ankylosing spondylitis, hepatitis, and lupus erythematosus, neurodegenerative or psychiatric conditions, or metabolic diseases such as diabetes or obesity

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Adding Equation 16.63 and Equation 16.64 and canceling H 2 CO 3 from both sides give the following overall equation for the reaction of CO 2 with water to give a proton and the bicarbonate ion: Equation 16.65 The K value for the reaction in Equation 16.65 is the product of the true ionization constant for carbonic acid ( K a ) and the equilibrium constant ( K ) for the reaction of CO 2 (aq) with water to give carbonic acid