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References 1 AirakiM.Snchez-MorenoL.LeterrierM.BarrosoJ

These opposing roles of distinct PRDX isoforms suggest that PRDXs function not simply as antioxidant enzymes but as context-dependent determinants of ferroptosis sensitivity

Sixthly, the pathogenic mechanisms of diseases are exceedingly complex, involving genetic factors, environmental influences, and numerous unknown variables

The production of ROS is mainly secondary to enzymatic reactions involved in the respiratory chain, activity of cytochrome p-450, synthesis of prostaglandins and phagocytosis (Pizzino et al., 2017)