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As a coenzyme the biologically active form of the vitamin binds within a protein apoenzyme creating a holoenzyme, thereby increasing the resultant enzymes competence in terms of the diversity of reactions that it can catalyze

Comeau AM, Douglas GM, Langille MG

, In mice, these macrophages cause the programmed death of the endothelial cells by secreting the morphogen, Wnt7b

These results suggest that, rather than being blunted, inflammatory responses in seals are tightly regulated at both systemic and tissue levels and that modulation of these processes may contribute significantly to avoiding diving-induced inflammation