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Accumulating extra-synaptic glutamate due to the over-activation of microglia promotes aberrant synaptic signaling in PD and other neurodegenerative brain diseases (Iovino et al

Importantly, these pathways offer targets for intervention: blocking upstream mtDAMPs release or downstream receptors could blunt the harmful inflammation

2.3 H 2 S release ability of the compound and its influencing factors Subsequently, we systematically evaluated the H 2 S release profiles of the novel hydrogen sulfide (H 2 S) donor drug under simulated physiological conditions in vitro