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459,460 However, covalent conjugation also has drawbacks

Myelin associated oligodendrocyte protein ( MOBP ) gene has been associated with disease risk in several neurodegenerative diseases, including PSP [19, 41, 88], CBD [54], AD APOE -4 carriers [59], ALS [85] and PD [95], and has also been reported to be associated with white matter degradation and increased rates of decline in executive function in behavioural variant frontotemporal dementia [46]