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(4) Complex Ferroptosis involves multiple signaling pathways and molecular regulatory networks, including iron metabolism, lipid metabolism, antioxidant system, etc., which reflects the complexity of the ferroptosis pathway and provides a potential target for clinical intervention in related diseases (2325)

Similar to these studies, there are studies in which vitamin C (Reference Savran, Cicek and Doguc7) , resveratrol (Reference zgmen and Yeilot44) , quercetin (Reference Yuksel, Yuksel and Yagmurca45) , berberine (Reference Mehrzadi, Fatemi and Esmaeilizadeh48) and gallic acid (Reference Olayinka, Ore and Adeyemo43) were used to treat MTX-induced tissue damage

[DOI] [PubMed] [Google Scholar] Zsengellr ZK, Ellezian L, Brown D, Horvth B, Mukhopadhyay P, Kalyanaraman B, Parikh SM, Karumanchi SA, Stillman IE, Pacher P (2012) isplatin nephrotoxicity involves mitochondrial injury with impaired tubular mitochondrial enzyme activity

Fisetin Fisetin (5-deoxyquercetin