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Kiefer and Copley, 2002)

Moreover, 1000 g/mL GE completely reverses A-induced cytotoxicity ( There is also evidence indicating that Gastrodin can improve memory in mice, reduce the deposition of A amyloid plaques, the number of astrocytes and activated microglial cells, and decrease the expression of TNF- and IL-1 in N9 cells

Soritau O, Tomuleasa C, Aldea M, Petrushev B, Susman S, Gheban D, Ioani H, Cosis A, Brie I, Irimie A, Kacso G, Florian IS

Tian et al., 2022) have confirmed that Bifidobacteria can be used to treat depressive symptoms, but the underlying mechanisms have not been completely elucidated, which may be related to reducing the abundance of pathogenic bacteria, exerting the anti-inflammatory effects, improving the permeability of intestinal barrier, regulating the tryptophan levels, affecting 5-hydroxytryptamine (5-HT) synthesis, and regulating hypothalamus-pituitaryadrenal (HPA) axis (Figure 1)