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Tobe R, Yoo MH, Fradejas N, et al

Additionally, this pathway can inhibit activated protein kinase C and reduce coenzyme II (nicotinamide adenine dinucleotide phosphate, NADPH) activity, alleviate ER stress and lipid accumulation (Jin et al., 2021), scavenge accumulated oxidative products, and reverse oxidative stress damage in nerve cells, thereby delaying or preventing the progression of VaD

Sun et al., 2019)

Therefore, presumably due to its effects on glutathione peroxidase, auranofin treatment elevated cellular GSH levels and diminished GSSG, leading to a decrease in the GSSG/GSH ratio (Figure 5A)