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Malate generated in the TCA cycle can be converted to nicotinamide adenine dinucleotide phosphate (NADPH) under the catalysis of the malic enzyme (Son et al., 2013

Additional approaches include liposomal encapsulation, which mimics cell membrane structure to enhance cellular uptake, and emulsion-based systems that improve dispersion in water-based formulations

Rather than acting like a conventional pharmaceutical drug, GHK-Cu appears to function more like a biological signaling molecule

AGEs also contribute to the generation of ROS, and affect the expression of endothelial growth factors to damage endothelial function in penis [98]