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Introduction Redox balance is fundamental to maintaining cellular homeostasis, acting as an essential regulator of physiological processes such as cell signaling, transcription factor activation (e.g., NF-B, Nrf2), cell proliferation, and apoptosis [1, 2]

In addition, dendritic cells in the tumor microenvironment can secret IGF and support T-ALL growth by activating IGF-IR [189]

A molecule small enough to penetrate skin and scalp tissue

Exogenous ROS can be generated by environmental pollutants, such as heavy metals ( When ROS levels are elevated, glioma cells initiate their own antioxidant defence system in response to oxidative stress (OS)