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[4] It is substituted for tetrahydrofuran (THF) in some processes, because of its lower toxicity and higher boiling point (101 C, versus 66 C for THF)

The blockade of CB1 reduces fibrosis through the inhibition of angiotensin II (ANG II) signaling pathways (Rozenfeld et al., 2011) (Wengrower et al., 2012)