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Abstract Zingiber and Alpinia species (family: Zingiberaceae) are popularly used in food as spices and flavoring agents and in ethnomedicine to heal numerous diseases, including immune-related disorders

Niacin (vitamin B3) is the precursor to nicotinamide adenine dinucleotide (NAD) and its phosphate form (NADP), coenzymes involved in over 400 enzymatic reactions, particularly those of energy metabolism and the oxidative stress response

Dietary restriction improved gut permeability and eczema in some cases, though not all

At present, regulatory agencies like the FDA and the European Commission evaluate CQDs on a case-by-case basis, irrespective of a specific regulatory procedure as these nanomaterials do not fit neatly within existing classifications for pharmaceuticals, biologics, or medical devices [172]