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From culture flasks to clinical trials Among the molecules tested here to illustrate the individual response to the oxidative stress of fibroblasts cultured under stressful conditions, pioglitazone is worth discussing despite the lack of effect on cultured fibroblasts we have studied

These factual concerns, which constitute real obstacles in carrying out therapeutic trials in humans, allows understanding the reason of the failures of numerous trials using substances deemed promising in the initial phases carried out on so-called models

Psychopharmacology (Berl) 2018;235:3045-54

5.2 The Role of Glutamine Metabolism in Tumor-Associated Macrophages Macrophages in the tumor microenvironment can define the immune landscape of a tumor, depending on the cytokines that they produce