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Active levels of B12 can be used by the body while the inactive form cannot

doi: 10.1249/01.Mss.0000048861.57899.04 149 MizokamiTShimadaMSuzukiK

doi: 10.1053/j.gastro.2018.07.007 89 ShahS

LPS binding to TLR4 upregulates myeloid differentiation primary response 88 (MyD88)/TIR-domain-containing adapter-inducing interferon- (TRIF) expression [43], while ROS generation promotes thioredoxin-interacting protein (TXNIP) dissociation, upregulating Cyt-c release and subsequent NLRP3 inflammasome assembly