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The accumulation of matrix protein in diabetic kidneys is largely due to epithelial-to-mesenchymal transition (EMT) of tubular cells

Apr 2025;10(4):402-410

The mechanism is related to Wnt signaling, gut loss repairing, expansion of stem and progenitor cells, and inhibition of differentiation

however, the ROS production was decreased instead while there was no significant difference in the percentage of apoptotic and dead cells in the normal myometrial cell, which could have indicated the possibility of strawberry extract to only target the UF cells while maintaining a homeostatic condition in the normal myometrial cells, hence lesser side effect could be achieved with the use of the strawberry extract