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Del Arco A., Morcillo J., MartnezMorales J

this may reflect transitions in insulin resistance, immune activation, and redox balance in prediabetes

However, ongoing studies have revealed that the multifaceted role of IFNs in the antitumor response during anti-PD treatment involves not only the classical JAK-STAT signaling pathway but also various noncanonical pathways that can lead to diverse outcomes, contributing to either tumor progression or tumor regression under certain conditions