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To develop kinase inhibitors that simultaneously target Src, AXL and IGF-1R activities, Lee and colleagues (2021) synthesized a series of compounds based on phenylpyrazolo[3,4-d]pyrimidine conjugation with 2,4-bis-arylamino-1,3-pyrimidines (I2)

[PMC free article: PMC10014511] [PubMed: 36937644] (65 year old man living in Germany developed jaundice within 4 weeks of starting ashwagandha for troubled thoughts [bilirubin 17.3 mg/dL, ALT 54 U/L, Alk P 298 U/L], resolving within 5 months of stopping)

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25-35 minutes post-injection youll notice shakiness, slight dizziness, or brain fog if you havent eaten carbs