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These are different biological axes

Cell 31 (6), 722733 (2014)

Nutrient Spotlight: NAD+ Nicotinamide Adenine Dinucleotide (NAD+) might sound like complex chemistry, but its effects on anxiety can be remarkably straightforward

Originally developed in Russia by Professor Vladimir Khavinson, the substance was designed to mimic the effect of a naturally occurring peptide in the pineal glanda small formation in the brain that helps regulate sleep patterns by producing melatonin