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However, this level may decrease during physical stress or illness

Effects of the circadian rhythm gene period 1 ( Per1 ) on psychosocial stress-induced alcohol drinking

2023 Lee et al

In rheumatoid arthritis -associated interstitial lung disease, elevated PAD2 expression in lung fibroblasts promoted a pro-fibrotic phenotype, while overexpression of syndecan-2 (SDC2) inhibited PAD2 and protected against BLM-induced fibrosis [94]