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Specifically, CAR T cells in the day 28 BM of LTR had significantly higher expression of mTOR, pS6, pAKT (mTOR and pAKT pathways) and the metabolic sensor AMPK, as well as significant increases in the fermentative glycolysis enzyme LDHA, the endogenous fatty acid metabolism enzymes SCD1, LAL, and CD45RA, suggesting an effector immunometabolic phenotype

The likelihood of this is significantly higher for those with prior heart conditions

Caffeine and EGCG significantly reduced the abnormal expression of Cxcr4, Cx3cr1, Shc2 , and Cx3cl1 induced by an HFHC diet