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In the context of tumor immunity, TNBC cells secrete factors that induce Jag-1 expression in MDSCs through the NFB-p65 pathway

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It also suppresses the phosphorylation of the signal transduction and activation of transcription 3 (STAT3) via CDK4 to reduce the production of interleukin 6 (IL-6) (Yan et al., 2022b)