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Long-term safety beyond 12 weeks has not been formally studied in large populations

Leptin sensitivity plays a crucial role in energy status, thyroid hormone production, and reproductive status, and GLP1 receptors in the brain may have downstream effects on the leptin-melanocortin pathway 6m0s

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In the Swedish ABIS cohort, oxPTM-INS-Ab were present in 82% children progressing to clinical T1D compared to 19% in those who did not progress despite having one or more standard islet-autoantibodies after a median follow-up of 10.8 years (interquartile range 7.7-12.8)