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They serve as the primary line of defense, clearing pathogens, endotoxins, and damaged cell debris from the bloodstream while also regulating liver immunity [45]

Under physiological conditions, the Neh2 structural domain of Nrf2 binds to Kelch-like ECH-associated protein 1 (Keap1) in the cytoplasm, facilitating Nrf2 ubiquitination and subsequent degradation ( 3.1.3 TRPM4 channels and endothelial dysfunction in atherosclerosis Ye et al

Juul K, Tybjaerg-Hansen A, Marklund S, Lange P, Nordestgaard BG: Genetically increased antioxidative protection and decreased chronic obstructive pulmonary disease