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Artesunate inhibits TGF-1-induced epithelial-to-mesenchymal differentiation (EMT) and RLE-6TN cell proliferation by upregulating Smad7 mRNA and protein expressions and downregulating Smad3, ACTA2, and Vim mRNA expressions ( 5.2.4 Promotes iron-mediated autophagy Wang et al

The tumors tortuous and hyperpermeable vessels [13,14,15,16] and the near absence of functional lymphatic vessels [17, 18] raise the interstitial fluid pressure (IFP) within breast tumors (Table 2)

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Nanoparticle formulations of the Parkinsons drug, selegiline, resulted in 12-20 fold increases in brain concentrations in laboratory animals compared to delivering the drug orally