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Nevertheless, several difficulties are encountered in the implementation of these treatment methods, such as the requirements of technical expertise in purifying small molecules, the dosage of small purified molecules to treatment, whether the harmful genes among the opportunistic pathogenic bacteria can be completely knocked out, and whether knocking out these bacterial genes have potential risks implications to the host health

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Despite its widespread clinical utility, oral N-Acetyl-L-Cysteine is characterized by remarkably poor bioavailability