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Studies on subjects undergoing KD show that KBs are important mediators of inflammation and oxidative stress

While emerging evidence suggests efficacy in RSE and SRSE, clinical application in adult intensive care unit (ICU) settings remains inconsistent

The roles of other metabolic pathways, such as cholesterol metabolism, and some immune cells, such as natural killer (NK) and CD4+ T cells, are still unclear, and the role of metabolic reprogramming in immune cells remains to be explored