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Serum metabolomic profiling identifies key metabolic signatures associated with pathogenesis of alcoholic liver disease in humans

In rodent studies, lutein may help reduce oxidative stress, confirmed by a decrease in extracellular signal-regulated kinase (ERK) activation and brain-derived neurotrophic factor (BDNF), along with an increase in glutathione (GSH) and glutathione peroxidase (GPx)

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There, they may exert antiviral or anti-inflammatory effects by inducing ferroptosis or covalently modifying key regulators such as Keap1 and IKK via peroxide bridges or Michael addition (Orosco and Quimque, 2024