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Despite the prominence of aberrant TDP-43 accumulation in most forms of ALS, it is a heterogenous disease with multiple aberrant pathogenic mechanisms implicated in progression, which contributes to challenges in disease modeling and developing a single disease-modifying therapy

The features of acetone, 2-ethyl-1-hexanol and a tetrahydroisoquinoline derivate were selected in model I.A, which included only VOC measurements

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Here's what gets us excited: if a relatively small dose of oral glutathione (remember, only 20% gets absorbed) showed these benefits, imagine what IV delivery of therapeutic doses might accomplish