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Repositioning of thiourea-containing drugs as tyrosinase inhibitors

Gastroenterology 146 , 789800.e788 (2014)

System Xc was thought as target of IFN to regulate ferroptosis since expressions of SLC7A11 and SLC3A2 were both significantly decreased

395 In other words, ZIP4 upregulated the expression of ZEB1 in PC, which in turn induced a substantial downregulation of gemcitabine uptake protein ENT1 by integrin 31, ultimately limiting drug internalization through activation of the MAP kinase JNK