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In order to reconcile short comings and difficulties in accurately defining and classifying the severity of HE, in 1998 the World Organisation of Gastroenterology introduced a multiaxial definition of HE [5], which categorized HE according to

Therefore, the outcome in our study has High reliability

These findings seem to be interesting and they seem to indicate that Se also has a dual role in orbital fibroblasts, i.e., under conditions of oxidative stress without cytotoxicity, Se can inhibit the release of pro-inflammatory factors and hyaluronic acid