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The pharmacology of the antioxidant lipoic acid

In recent years, adductomics have begun to emerge as a new omics tool that aims to study the totality of covalent adducts bound to tissue/blood nucleophiles, developed as a basis for characterizing essentially all reactive electrophiles in biospecimens

Indeed, an age related decrease or impairment in cerebral perfusion has been implicated in several neurological disorders associated with poor cognitive ability, such as brain damage, clinical dementia and Alzheimers disease [92,93]

L-2-oxothiazolidine-4-carboxylic acid (OTC) treatment attenuated plasma and tissue P-selectin levels, suggesting that the upregulation of P-selectin in hyperhomocysteinemic mice is also regulated by redox mechanisms [61]