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[16] Andres E, Noel E, Goichot B

While attention has been focused on the elevation of homocysteine recent research points out that the methionine cycle can be compromised at other points leading to deficiencies with normal or low levels of homocysteine

Metabolites and the tumor microenvironment: from cellular mechanisms to systemic metabolism

In this regard, increased loss of glutathione may change the intracellular environment to a prooxidant state and thereby caused prominent changes in gene expression, which is ultimately evolving into a malignant state [26]