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Downregulation of mitochondrial fusion can spatially isolate damaged mitochondria for efficient removal by mitophagy, highlighting the selectivity of oxidative conditions in a ROS signalling cascade that dominantly triggers selective mitophagy 40

Reactions were prepared in a buffer containing 50 mM Tris-HCl, 10 mM MgCl 2 , 2 mM DTT, 1 mM ATP, 0.01% Triton X-100, 1 mM peptide, and varying concentrations of [- 32 P] ATP depending on radioactive decay

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No improvement on the other hand would suggest that MTHFR may not be the dominant cause of fatigue even if MTHFR testing is positive