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The pathological PNI status was assessed according to the definition proposed by Liebig [8]: cancer cell in close proximity to nerve and involving at least 33% of its circumference or tumor cells within any of the 3 layers of the nerve sheath

Activating the GSH system alleviates the progression of the myocardial injury by blocking the ferroptosis pathway and oxidative stress, which provides a promising therapeutic strategy for cardiac diseases

This gradual increase is essential to minimize gastrointestinal side effects and enhance patient tolerance

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