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Macro-B12 is commonly defined as the fraction of B12 removed by precipitation with polyethylene glycol (PEG)

If side effects do occur, they are generally mild and may include: Pain, discomfort, swelling, or redness at the injection site Diarrhea Headache Bloating Nausea Numbness or tingling Serious side effects are rare and may include: Confusion Dizziness or fainting Muscle pain, cramps, or weakness Extreme thirst Facial flushing Frequent urination Palpitations Fatigue Difficulty breathing Coughing or noisy breathing (wheezing) Extreme pain, swelling, warmth or tenderness in one leg Difficulty swallowing Rash Itching over the body If you experience serious side effects, contact your doctor right away

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Others have assessed B12 shots for reducing deficiency due to other causes