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For instance, the D/L enantiomers of 2-microglobulin K3 form independent fibrils without cross-reactivity, whereas the D/L mixture of L4K8L4 undergoes a complete assembly pathway transformation, resulting in non-fibrous spherical aggregates

Additionally, accumulation of free toxic compounds such as long chain fatty acid surrounding the mitochondria induces mitochondrial membrane permeability because of mitochondrial membrane depolarization and membrane canals formation