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Description

The acidic pH (approximately 4.5) required for hydrolases to function is set by an ATP-coupled proton pump, the vacuolar H + -ATPase (v-ATPase), and ion channels

An increasing body of evidence indicates that natural bioactive compounds may provide adjunctive therapeutic advantages with a reduced incidence of adverse effects in comparison to traditional antidepressants

Bacteriophages modulate gut microbiota by lysing host bacteria or altering their physiological functions [104]

Notably, DNA oxidation products such as 8-OHdG have been found at elevated levels in MASLD patients and have shown a correlation with disease severity [101, 121, 122]