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Consequently, these nanocarriers are designed to facilitate endosomal escape and ensure robust delivery to organelles such as the nucleus, lysosomes, mitochondria, Golgi apparatus, and endoplasmic reticulum [164, 166]

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For quantification from animal tissues, mice were sacrificed by cervical dislocation followed by cessation of blood circulation, and ~50 mg of each tissue was immediately dissected and snap-frozen in liquid nitrogen