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Introduction Nowadays, cancer is a main public health problem all over the world

Fluorescence images were acquired using a Deltavision real-time microscope (Applied Precision), a thunder microscope (Leica) or an Apotome Weiss microscope with Deltavision imaging software, Thunder Leica image acquisition software or Apotome Zeiss Imaging software, respectively

Results indicate ALP exposure during adolescence potentiates the rewarding properties of MOR and induces persistent changes in ERK-signaling within the VTA-NAc pathway, a brain circuit highly implicated in the regulation of both drug reward and mood- related behaviors

Understanding this journey is not merely a pharmacokinetic exercise but is fundamental to explaining the disparate outcomes observed in clinical trials and for designing precision-based interventions