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Consider discussing B12 testing with your vet if your dog has: Had chronic or intermittent diarrhoea for more than a few weeks without a clear resolved cause Lost weight progressively despite adequate food intake Been diagnosed with a chronic gut condition, such as inflammatory bowel disease or exocrine pancreatic insufficiency A history of poor early nutrition, such as a recently rescued stray or previously malnourished dog Been through multiple courses of treatment for digestive symptoms without sustained improvement A young dog or puppy that is not developing or gaining weight as expected Causes of Vitamin B12 Deficiency in Dogs Vitamin B12 deficiency in dogs is almost always caused by a problem with absorption rather than a lack of B12 in the diet

When a source says one is stronger than the other, it is lining up REDEFINE 1s roughly 20.4% at 68 weeks against SURMOUNT-1s roughly 20.9% at 72 weeks two numbers from two different trials, in different populations, over different durations, against different comparators

However, some cohorts show no association or even contradictory trends depending on age, BMI, or genetic background

Nonetheless, one must consider the various caveats that accompany their application as biomarkers or therapeutic targets in MDD