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After being blocked with 5% dry milk in TBST, the sections were probed overnight at 4 C with primary antibodies against Collagen I (1:800), PGC-1 (1:1000), Nrf1 (1:200), Tim23 (1:50), Drp1 (1:200), P-Drp1ser616 (1:1000), ACSL4 (1:100), FTH1 (1:200), GPX4 (1:2000), TFR1 (1:500), Nrf2 (1:200), P-MLKL (1:200), GSDMD-N (1:200), Cleaved caspase-3 (1:50) and -SMA (1:2000)

It has been implicated as a potential medicine for the treatment of tuberculosis (Simbirtsev et al., 2003) and a potent antiviral therapeutic agent against genital HSV-2 recurrent disease (Rose et al., 2008)

However, it is noteworthy that liver inflammation, including infiltration of inflammatory cells and dilated sinusoids, was observed in rats treated with an SNRI venlafaxine, as well (Paulis et al