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Research indicates that COVID-19 pandemic restrictions to in-person research greatly increased survey fatigue as researchers moved to using on-line methods [416 417] and while this affects all groups, differential effects are seen across industries [418] and demographics

(2000) The combination of insulin-like growth factor I and insulin-like growth factor-binding protein-3 reduces insulin requirements in insulin-dependent type 1 diabetes: evidence for in vivo biological activity

It is widely used in laboratory experiments

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