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Intriguingly, TLR2 signaling may, in specific contexts, exert protective effects by inducing anti-inflammatory factors like IL-10[58], suggesting context-dependent functionalities among TLR family members

K., Boyd, J

Therefore, although high concentrations of cytokines inhibit the production of red blood cells and reduce the consumption of plasma iron, the generation of nontransferrin-bound iron required for pathogen growth also decreases, leading to an increase in copper content but a decrease in the iron level in peripheral blood [204]

The wide range of CP dosages used in models, some exceeding clinically relevant exposures, further complicates relevance to patient care