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Carnitine deficiency increases susceptibility to bupivacaine-induced cardiotoxicity in rats

These changes hinder nutrient and water uptake, further intensifying stress, as observed in various plants under stress conditions [10, 40, 41]

Current knowledge suggests that new therapies aiming at restoring the energy balance in the heart should be used on top of current therapies to better treat HF patients and improve quality of life and possibly survival