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In the 1970s, the insulin receptor was discovered, and 10 years later, its tyrosine kinase activity was demonstrated

The cycle above utilizes key antioxidants such as glutathione (GSH) and ascorbate (AsA) and enzymes such as dehydroascorbate reductase (DHAR), glutathione reductase (GR), monodehydroascorbate reductase (MDHAR), and ascorbate peroxidase (APX)