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de La Puente Yage, M., Collado Yurrita, L., Ciudad Cabaas, M

Molecules of free radicals with unpaired electrons in their outer shells, including superoxide radical (O 2 - ), hydrogen peroxide (H 2 O 2 ), and the hydroxyl radical (HO) produced in autoxidation reactions are important components of ROS in the cell [8]

At therapeutic concentrations (100200 M, achievable via intratumoral delivery), I3A activates the AhR/cAMP response element-binding protein (CREB) axis in CD8 + T cells: specifically, AhR recruits CREB to the IFN- promoter, inducing CREB phosphorylation at Ser133 to amplify type 1 cytotoxic T cell (Tc1) differentiation and tumor cytotoxicity (113, 171)